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Meeting Announcement
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Date: Wednesday, November 19th, 2014
Topic: "Inhibition of Inhibition: Mechanism of CTLA-4 and PD-1-modulating Antibodies for Oncology"
Speaker: Nils Lonberg
 Senior Vice President, Biologics Discovery
Bristol-Myers Squibb
Location:

The Holiday Inn
275 S Airport Blvd
South San Francisco, CA 94080
650-873-3550 | Map
Next door to the SSF Conference Center
Directions at www.hisfo.com

Price:

$45 before 9PM, Monday, November 17th
$55 on-site
$35 full-time students pre-registration
$45 full-time students on-site
$3 service fees will be added to the pre-registration prices

6:00 PM - networking
7:00 PM - dinner
8:00 PM - presentation

Abstract:

The immune response to a tumor is a complex, orchestrated network of stimulatory and inhibitory signals. Antibodies that target inhibitory receptors such as CTLA-4 and PD-1 appear to restore cancer patient's endogenous immune responses to their disease. The clinical experience with these antibodies has shaped the immune-oncology pipeline of Bristol-Myers Squibb.

Ipilimumab, an antibody directed against CTLA-4 (cytotoxic t-lymphocyte-associated antigen 4) is now approved for the treatment of metastatic melanoma. Nivolumab, an antibody directed against PD-1 (programmed death-1) is now being tested in multiple phase 3 trials in multiple patient populations, with encouraging results in metastatic melanoma recently published. Preclinical and clinical investigations of the mechanism of action of these drugs will be reviewed. These mechanisms provides guidance for the discovery and development of new agents for the treatment of cancer.

Biography:

Dr. Lonberg is Senior VP at the Bristol-Myers Squibb Biologics Discovery site in California, where cancer immunotherapy is a major research focus. Dr. Lonberg began his career in industry in the research group at GenPharm International that developed genetically engineered strains of mice with germline-configuration human immunoglobulin genes. These transgenic animals have been used to discover over two dozen clinical-stage human sequence antibodies, including five FDA approved products. In 1997, GenPharm was acquired by Medarex, which was in turn acquired by Bristol-Myers Squibb in 2009.

Dr. Lonberg has published in the areas of molecular biology, developmental biology, immunology, and biotechnology. He is an inventor on numerous issued patents, including the third US patent covering a genetically engineered animal, and on patents covering seven marketed therapeutic drugs. He received his PhD in Biochemistry & Molecular Biology from Harvard University in 1985.

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