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Meeting Announcement
Date: Wednesday, June 24th, 2015
Topic: "The CRISPR/Cas9 Genome Editing Revolution"
Speaker: Jacob Corn, Ph.D.
Scientific Director
Innovative Genomics Initiative
UC Berkley
Location:

The Holiday Inn
275 S Airport Blvd
South San Francisco, CA 94080
650-873-3550 | Map
Next door to the SSF Conference Center
Directions at www.hisfo.com

Price:

$50 before 9PM, Monday, June 22nd
$60 on-site
$40 full-time students pre-registration
$50 full-time students on-site
$3 service fee will be added to the pre-registration price

6:00 PM - networking
7:00 PM - dinner
8:00 PM - presentation





Platinum Sponsors

Novartis
Pii

Gold Sponsors

Patheon
PPS
ChanTest
ReImagine Science
Deloitte
RHS Financial
MSL Group
SomaLogic
Pharmatek

Silver Sponsors

WAVSIP
Formurex
PerkinElmer

Abstract:

The recent development of CRISPR technology for targeted genomic editing may enable disruptive advances in biology and medicine in a very short time frame. Derived from viral-mediated defense systems, Cas9-mediated genomic engineering together with rapidly developing synthetic biology tools are applicable to model systems, plants, animals, and even human cells.

It is now possible to introduce mutations to evaluate gene function, generate models of human genetic disease, perform gene correction, chromosomally integrate synthetic gene networks that perform complex regulatory functions, and redesign genome structure or build whole genomes from scratch. In the near term, gene editing could revolutionize the way preclinical research is carried out, enabling custom-designed safety models (e.g. humanized rats), highly engineered cell lines to meld target and phenotypic screening, and synthetic systems for enhanced drug production. In the longer term, precise replacement of one sequence with another holds promise as a therapeutic application in diseases such as muscular dystrophy and severe combined immunodeficiency. Dr. Korn will discuss how CRISPR-Cas9 was discovered, how it was turned into a gene editing technology, recent results uncovering mechanisms by which cells repair Cas9-induced DNA breaks, and will introduce a clinical project in hematological disease.

Biography:

Jacob Corn received his PhD in the lab of James Berger at University of California, Berkeley, where his work helped redefine the organization of the bacterial replication fork and he was awarded the Nicholas Cozzarelli and Harold M. Weintraub graduate student awards. As a Jane Coffin Childs postdoctoral fellow with David Baker at the University of Washington, he computationally designed protein-protein interactions from scratch as part of a team that developed the first bipartite synthetic interaction pair and binding partners that targeted therapeutically-relevant proteins. After his postdoctoral training, Jacob was a group and project team leader at Genentech in the department of Early Discovery Biochemistry, leading multidisciplinary teams to interrogate mechanism and feasibility for challenging therapeutic pathways in the areas of neurobiology, infectious disease, and oncology.

He joined the Innovative Genomics Initiative as Scientific Director in May 2014.

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